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A-366 044SB069 exhibits high binding affinity to

SKU: 27305646319

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Description

exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0

57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18

The inactive NEPi precursor

PF 543 Citrate

which is an enzyme that controls the generation of two cytokines

A-366 044SB069 exhibits high binding affinity toA 366 is a potent, highly selective, peptide competitive histone methyltransferase G9a inhibitor with IC50s of 3. 3 and 38 nM for G9a and GLP (EHMT1), respectively. A 366 shows >1000 fold selectivity over 21 other methyltransferases. A 366 is also a potent, nanomolar inhibitor of the Spindlin1 H3K4me3 interaction (IC50=182. 6 nM). A 366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the

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